Thermo Scientific™ SIA (succinimidyl iodoacetate)

Crosslink amines to sulfhydryls with this very short crosslinker composed of NHS-ester and iodoacetyl (haloacetyl) groups at ends of a 3-atom (1.5A) spacer arm.

Brand:  Thermo Scientific™ 22349

Product Code. 10465944

Description

Thermo Scientific™ Pierce SIA is a very short (1.5 Å) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl reactive groups.

Suited to capturing amine and sulfhydryl groups in very close proximity

Highlights:

• Reactive groups: NHS ester and iodoacetyl
• Reactive toward: amino and sulfhydryl groups

Specifications

• Chemical Reactivity: Amine-Sulfhydryl
• Description: SIA
• PEGylated: No
• Content And Storage: Upon receipt store at 4°C protected from moisture.
• Shipping Condition: Ambient
• Labeling Method: Chemical Labeling
• Reactive Moiety: Haloacetyl, NHS Ester
• Form: Solid
• Solubility: DMF, DMSO
• Water Soluble: No

• Cleavable: No
• Molecular Weight (g/mol): 283.02
• Spacer Arm Length: 1.5 Å
• Cell Permeability: Yes
• Product Line: Pierce™
• Crosslinker Type: Heterobifunctional
• Spacer: Short (<10 Å)
• Quantity: 50 mg
• Format: Standard
• Product Type: Crosslinker

Safety and Handling

Product Identifier

• SIA (succinimidyl iodoacetate)

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : N-Hydroxysuccinimidyl iodoacetate

For Research Use Only. Not for use in diagnostic procedures.