Thermo Scientific™ Pierce™ SMCC

No-Weigh™ Format

Product Code	Brand	Quantity
10066813	Thermo Scientific™ 22360	50 mg
15890853	Thermo Scientific™ A35394	10 x 1 mg

Description

Thermo Scientific™ Pierce SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane-stabilized spacer arm (8.3 Ås).

Highlights:

• Cyclohexane bridge adds stability to the maleimide-reactive group; N-(4-carboxycyclohexylmethyl) maleimide groups are stable for 64 hours in 0.1 M sodium phosphate buffer, pH 7.0 at 4°C
• Ideal for coupling enzymes to antibodies
• Reactive groups: NHS-ester and maleimide
• Reactive toward: amino and sulfhydryl groups

Specifications

• Chemical Reactivity: Amine-Sulfhydryl
• Description: SMCC
• PEGylated: No
• Content And Storage: Upon receipt store desiccated at 4°C.
• Shipping Condition: Ambient
• Crosslinker Type: Heterobifunctional
• Spacer: Short (<10 Å)
• Solubility: DMF, DMSO
• Water Soluble: No

• Cleavable: By Thiols
• Molecular Weight (g/mol): 334.32
• Spacer Arm Length: 8.3 Å
• Cell Permeability: Yes
• Labeling Method: Chemical Labeling
• Reactive Moiety: Maleimide, NHS Ester
• Form: Powder
• Format: Standard, Single-use
• Product Type: Crosslinker

Safety and Handling

Product Identifier

• SMCC

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P264-Wash hands thoroughly after handling.
• P271-Use only outdoors or in a well-ventilated area.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.
• P362+P364-Take off contaminated clothing and wash it before reuse.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : Succinimidyl-trans-4-(N-maleimidylmethyl)cyclohexane-1-carboxylate

For Research Use Only. Not for use in diagnostic procedures.