PRE-084 hydrochloride, Tocris Bioscience™

Description

Highly selective σ1 agonist

High affinity, selective σ1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). Selective over PCP receptors (IC50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo. Also exhibits protective effects in PC6.3 cells expressing mutant huntingtin by activating NF-κB signaling.

Specifications

Chemical Identifiers

• CAS: 138847-85-5
• Molecular Formula: C19H27NO3
• Molecular Weight (g/mol): 317.43
• MDL Number: MFCD00673883
• InChI Key: RQHKZUBCUZVZEF-UHFFFAOYSA-N
• Synonym: pre-084 hydrochloride, 2-morpholin-4-yl ethyl 1-phenylcyclohexane-1-carboxylate hydrochloride, pre-084, solid, 2-4-morpholinethyl 1-phenylcyclohexanecarboxylate hydrochloride, 2-4-morpholinethyl-1-phenylcyclohexanecarboxylate hydrochloride, 2-4-morpholinyl ethyl 1-phenylcyclohexanecarboxylate hydrochloride
• PubChem CID: 11314197
• IUPAC Name: 2-(morpholin-4-yl)ethyl 1-phenylcyclohexane-1-carboxylate
• SMILES: O=C(OCCN1CCOCC1)C1(CCCCC1)C1=CC=CC=C1

• Quantity: 10 mg
• Formula Weight: 353.89
• Percent Purity: >99%
• Chemical Name or Material: PRE-084 hydrochloride