Prednisone, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity	Packaging
13458638	Thermo Scientific Acros 448950050	5 g	Glass bottle
13468638	Thermo Scientific Acros 448950250	25 g	Glass Bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities

• It shows antineoplastic and adrenergic activities against hormone-sensitive cancer cells

• This compound binds to its receptors and enters the nucleus activating specific nuclear receptors, resulting in an altered gene expression and inhibiting proinflammatory cytokine production

Applications

• Prednisone can reduce circulating lymphocytes, promote cell differentiation, and stimulate apoptosis in sensitive tumor cell lines

• It is considered a prodrug that is converted by the liver into prednisolone which is the active steroid compound

• It is also used in some studies to investigate the effects of daily administration of MIDD0301, on the animal and organs weights and hematological profile

Chemical Identifiers

• CAS: 53-03-2
• Molecular Weight (g/mol): 358.434
• Synonym: prednisone, deltasone, dehydrocortisone, decortin, meticorten, orasone, prednison, rectodelt, ultracorten, dacortin
• ChEBI: CHEBI:8382
• SMILES: CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C

• Molecular Formula: C21H26O5
• InChI Key: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
• PubChem CID: 5865
• IUPAC Name: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

Specifications

• CAS: 53-03-2
• Molecular Formula: C21H26O5
• InChI Key: XOFYZVNMUHMLCC-ZPOLXVRWSA-N
• IUPAC Name: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
• PubChem CID: 5865
• Formula Weight: 358.43

• Assay Percent Range: 98%
• Synonym: prednisone, deltasone, dehydrocortisone, decortin, meticorten, orasone, prednison, rectodelt, ultracorten, dacortin
• SMILES: CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
• Molecular Weight (g/mol): 358.434
• ChEBI: CHEBI:8382
• Chemical Name or Material: Prednisone

Safety and Handling

Product Identifier

• Prednisone

Signal Word

• Warning

Hazard Category

• Reproductive toxicity Category 2

Hazard Statement

• H361-Suspected of damaging fertility or the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P202-Do not handle until all safety precautions have been read and understood.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only