Progesterone Receptor Monoclonal Antibody (SP2), Invitrogen™

Rabbit Monoclonal Antibody

Brand:  Invitrogen MA514505

Product Code. 11325083

Description

MA5-14505 targets Progesterone Receptor in IHC (P) and WB applications and shows reactivity with Human samples. MA5-14505 has been successfully used in western blotting, immunofluorescence, and immunohistochemistry analysis of Progesterone Receptor in human and mouse samples. The MA5-14505 immunogen is recombinant protein encoding human progesterone receptor 412-526 aa.

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Specifications

• Antigen: Progesterone Receptor
• Classification: Monoclonal
• Concentration: 0.08 mg/mL
• Formulation: PBS with 1% BSA and 0.1% sodium azide; pH 7.2
• Gene Accession No.: P06401
• Gene Symbols: PGR
• Immunogen: Recombinant protein encoding human progesterone receptor 412-526 aa
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: SP2
• Conjugate: Unconjugated
• Gene: PGR
• Gene Alias: 9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5241
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid