STEMCELL Technologies Prostaglandin E2

Prostanoid pathway activator; Activates prostaglandin receptors EP1, EP2, EP3 and EP4

Product Code	Brand	Quantity
17110042	STEMCELL Technologies 72194	5 mg
15692517	STEMCELL Technologies 72192	1 mg

Description

• Prostaglandin E₂ (PGE₂) is the most biologically active and well-studied prostaglandin
• It binds with very high affinity to the EP1, EP2, EP3, and EP4 receptors (Ki = 9.1, 4.9, 0.33, 0.79 nM respectively)
• (Abramovitz et al.), Bos et al.)
• Required for the development of hematopoietic stem cells (HSCs) in mice and zebrafish (North et al.)
• Improves engraftment of mouse HSCs, possibly through increasing homing, survival, and/or self-renewal (Hoggatt et al. 2009, Hoggatt et al.) 2013, North et al.)
• Promotes differentiation of hematopoietic progenitor cells from mouse, macaque, and human embryonic stem cells (Gori et al.), North et al.), Woods et al.)
• Promotes differentiation of myeloid-derived suppressor cells from hematopoietic progenitors (Sinha et al.)
• Promotes differentiation of Th17 cells from naïve T-cells (Boniface et al.)

Specifications

• CAS: 363-24-6
• Molecular Formula: C₂₀H₃₂O₅