Protein Z Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA5120422

Product Code. 17721824

Description

Positive test controls include: HepG2, 293T, Mouse kidney, Rat liver, Rat kidney. The target is usually found in the following locations: Secreted. Immunogen sequence: SLLHRNITVK TYFNRTSQDP LMIKITHVHV HMRYDADAGE NDLSLLELEW PIQCPGAGLP VCTPEKDFAE HLLIPRTRGL LSGWARNGTD LGNSLTTRPV TLVEGEECGQ VLNVTVTTRT Y

PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Specifications

• Antigen: Protein Z
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PROZ
• Gene Alias: protein Z, vitamin K dependent plasma glycoprotein; protein Z, vitamin K-dependent plasma glycoprotein; PROZ; PZ; vitamin K-dependent protein Z; vitamin K-dependent protein Z precursor variant 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 306608, 66901, 8858
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 2.50 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P22891, Q9CQW3
• Gene Symbols: PROZ
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 220-340 of human PROZ (NP_003882.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG