PX 12, Tocris Bioscience™

Description

Thioredoxin-1 inhibitor

Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

Specifications

Chemical Identifiers

• CAS: 141400-58-0
• Molecular Formula: C7H12N2S2
• Molecular Weight (g/mol): 188.31
• MDL Number: MFCD18086851
• InChI Key: BPBPYQWMFCTCNG-UHFFFAOYNA-N
• Synonym: 2-sec-butyldisulfanyl-1h-imidazole, 2-1-methylpropyl dithio-1h-imidazole, 2-butan-2-yldisulfanyl-1h-imidazole, 1h-imidazole,2-1-methylpropyl dithio, 1h-imidazole, 2-1-methylpropyl dithio, iv 2 compound, iv-2 compound, 1-methylpropyl-2-imidazolyl disulfide
• PubChem CID: 219104
• IUPAC Name: 2-(butan-2-yldisulfanyl)-1H-imidazole
• SMILES: CCC(C)SSC1=NC=CN1

• Quantity: 50 mg
• Formula Weight: 188.31
• Percent Purity: >99%
• Chemical Name or Material: PX 12