Quinine hemisulfate monohydrate, 98+%, Thermo Scientific Chemicals

Description

Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Quinine hemisulfate monohydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent. It inhibits mitochondrial ATP-regulated potassium channel. It is also used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Solubility
Soluble in a mixture of chloroform and absolute alcohol (2:1).

Notes
Light sensitive. Incompatible with strong oxidizing agents, alkalis, ammonia, strong bases and iodine.

Specifications

Chemical Identifiers

• CAS: 6119-70-6
• Molecular Formula: C40H54N4O10S
• Molecular Weight (g/mol): 782.95
• MDL Number: MFCD00150790
• InChI Key: ZHNFLHYOFXQIOW-OIGVVMIYNA-N
• Synonym: Quinine sulfate (2:1) (salt) dihydrate; Quinine sulfate dihydrate
• PubChem CID: 134129495
• IUPAC Name: (R)-[(2R,4R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;tetrahydrate
• SMILES: O.O.OS(O)(=O)=O.[H][C@@]1(CN2CCC1C[C@@]2([H])[C@H](O)C1=C2C=C(OC)C=CC2=NC=C1)C=C.[H][C@@]1(CN2CCC1C[C@@]2([H])[C@H](O)C1=C2C=C(OC)C=CC2=NC=C1)C=C

• Melting Point: 217°C to 218°C (decomposition)
• Odor: Odorless
• Quantity: 10 g
• Beilstein: 6113937
• Sensitivity: Light sensitive
• Merck Index: 14,8061
• Solubility Information: Soluble in a mixture of chloroform and absolute alcohol (2:1).
• Optical Rotation: −241° (c=2 in 0.1M HCl)
• Formula Weight: 391.47 (373.46 Anhydrous)
• Percent Purity: 99%
• Chemical Name or Material: Quinine hemisulfate monohydrate

Safety and Handling

Product Identifier

• Quinine hemisulfate monohydrate

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Quinine, sulfate (2:1), dihydrate

RUO – Research Use Only