TLR4 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of TLR4.

Brand:  Abnova PAB25699.100ug

Product Code. 16025877

Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq

Specifications

• Antigen: TLR4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (5 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: TLR4
• Gene Symbols: TLR4
• Immunogen: A synthetic peptide corresponding to 14 amino acids at C-terminus of human TLR4.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: TLR4 antibody is predicted to not cross-react with other TLR protein family members.
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: ARMD10/CD284/TOLL/hToll
• Host Species: Rabbit
• Purification Method: Peptide affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 7099
• Target Species: Human
• Form: Liquid

For Research Use Only