TRAF6 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of TRAF6.

Brand:  Abnova PAB12896.100ug

Product Code. 16010237

Description

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq

Specifications

• Antigen: TRAF6
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of TRAF6.
• Formulation: In PBS (0.02% sodium azide)
• Gene Alias: MGC:3310/RNF85
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: TRAF6
• Gene Symbols: TRAF6
• Immunogen: A synthetic peptide corresponding to C-terminus 14 amino acids of human TRAF6.
• Regulatory Status: RUO
• Gene ID (Entrez): 7189
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only