Ribavirin, MP Biomedicals™

Description

Active against many DNA and RNA viruses. Ribavirin, MP Biomedicals is an antiviral compound that is active against RSV, HIV, HCV and other infectious agents. It is a nucleoside antimetabolite drug that interferes with duplication of viral genetic material

Ribavirin is used as an antiviral agent against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. It inhibits purine (GTP pools) biosynthesis and is a precursor to the di- and tri-phosphates that inhibit viral RNA-dependent RNA polymerases. Its metabolite, ribavirin 5'-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence. It is also an analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.

Specifications

Chemical Identifiers

• CAS: 36791-04-5
• Molecular Formula: C8H12N4O5
• Molecular Weight (g/mol): 244.207
• InChI Key: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• Synonym: ribavirin, tribavirin, virazole, rebetol, ribavirine, copegus, vilona, ribamide, ribamidil, ribasphere
• PubChem CID: 37542
• ChEBI: CHEBI:63580
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
• SMILES: C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N

• Melting Point: 173°C (literature)
• Loss on Drying: 0.04% (Lit.)
• Quantity: 250 mg
• Solubility Information: Soluble in water (20mg/mL, clear, colorless solution).
• Formula Weight: 244.2g/mol
• Percent Purity: >99%
• Physical Form: Powder

Safety and Handling

Product Identifier

• Ribavirin

Signal Word

• Danger

Hazard Category

• Reproductive toxicity Category 1A

Hazard Statement

• H360-May damage fertility or the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P202-Do not handle until all safety precautions have been read and understood.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P405-Store locked up.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : Ribavirin