Ribavirin, Tocris Bioscience™

Description

Serine protease inhibitor; inhibits tryptase

Antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (Ki ∽ 0.3 μM for the active metabolite, ribavirin triphosphate). Also inosine monophosphate dehydrogenase (IMPDH) inhibitor. Represses colony formation of primary AML-M5 progenitor cells (IC50 ∽ 1 μM); reduces disease severity in acute myeloid leukemia (AML). Inhibits cytopathic effect of SARS-CoV in Vero cells in vitro. Orally available.

Specifications

• CAS: 36791-04-5
• Molecular Formula: C8H12N4O5
• Quantity: 50 mg
• Synonym: ribavirin, tribavirin, virazole, rebetol, ribavirine, copegus, vilona, ribamide, ribamidil, ribasphere
• InChI Key: IWUCXVSUMQZMFG-AFCXAGJDSA-N
• SMILES: C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
• Molecular Weight (g/mol): 244.207
• PubChem CID: 37542
• ChEBI: CHEBI:63580
• Formula Weight: 244.2
• Percent Purity: >99%
• Chemical Name or Material: Protein-synthesizing GTPase Compounds