Rifabutin, 98%, Thermo Scientific Chemicals

Description

Rifabutin, CAS # 72559-06-09, is a broad-spectrum antibiotic with activity against mycobacteria, gram-positive and gram-negative bacteria.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Rifabutin is a compound with antibacterial activity most commonly used against Mycobacterium tuberculosis

Rifabutin is a derivative of Rifamycin S that acts through blocking RNA polymerase subunit beta (RpoB)

Rifabutin is an inducer as well as a substrate of CYP3A, a cytochrome P450 enzyme

Applications

Rifabutin may be used in pharmacokinetic laboratory studies and high-throughput drug screens

May be used in laboratory studies to determine drug resistance mutations present in Mycobacterium tuberculosis strains

Specifications

Chemical Identifiers

• CAS: 72559-06-9
• Molecular Formula: C46H62N4O11
• Molecular Weight (g/mol): 847.02
• MDL Number: MFCD00866816
• InChI Key: ATEBXHFBFRCZMA-VXTBVIBXSA-N
• Synonym: rifabutin, ansamycin, rifabutine, mycobutin, ansatipine, ansatipin, alfacid, rifabutina, rifabutinum, antibiotic lm 427
• PubChem CID: 57448257
• IUPAC Name: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxo-8,33-dioxa-24,27,29-triazaspiro[pentacyclo[23.6.1.1⁴,⁷.0⁵,³¹.0²⁶,³⁰]tritriacontane-28,4'-piperidin]-1,3,5(31),9,19,21,25,29-octaen-13-yl acetate
• SMILES: CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C)C(O)=C4C(=O)C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC5(CCN(CC(C)C)CC5)N=C1C4=C3C2=O

• Assay Percent Range: 97.5% min. (HPLC)
• Quantity: 5 g
• Formula Weight: 847
• Percent Purity: 98%
• Chemical Name or Material: Rifabutin

RUO – Research Use Only