Thermo Scientific Chemicals Rifampin, Molecular Biology Reagent

Description

Rifampin (rifampicin), CAS # 13292-46-1, is a synthetic rifamycin antibiotic that works by inhibiting RNA and DNA synthesis and exhibits activity against the tuberculosis microbe.

Antibiotic effective against mycobacteria. Can also inhibit DNA polymeraseRifampin is an antibiotic used in the treatment of tuberculosis and its related microbacterial infections. It is involved in the inhibition of DNA polymerase and RNA polymerase. As an antipruritic agent, it is used in the autoimmune cholestatic liver disease and primary biliary cirrhosis (PBC).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Rifampin is a rifamycin class antibiotic synthesized to resemble the compound isolated from Amycolatopsis rifamycinica

Applications

• Rifampin can be used as a bacteriostatic that prevents RNA and DNA synthesis, particularly in mycobacteria

• It may also act as an antineoplastic, a neuroprotective, and inhibitor of angiogenesis

Specifications

Chemical Identifiers

• CAS: 13292-46-1
• Molecular Formula: C43H58N4O12
• Molecular Weight (g/mol): 822.953
• MDL Number: MFCD00151389
• InChI Key: FZYOVNIOYYPUPY-HRJPTAQKSA-N
• Synonym: Rifampicin
• PubChem CID: 131839595
• SMILES: CC1C=CC=C(C(=O)NC2=C(C3=C(C(=C4C(=C3C(=O)C2=CNN5CCN(CC5)C)C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C

• Type: Rifampicin
• Physical Form: Powder
• Melting Point: 183°C to 188°C
• Color: Brown/Red to Orange
• Quantity: 5 g
• Beilstein: 5723476
• Merck Index: 14,8216
• Solubility Information: Soluble in DMSO or methanolSoluble in water,ethyl acetate,chloroform,methanol,tetrahydrofuran and dimethyl sulfoxide.
• Formula Weight: 822.94
• Grade: Molecular Biology
• Chemical Name or Material: Rifampin

Safety and Handling

Product Identifier

• Rifampin, Molecular Biology Grade

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H302-Harmful if swallowed.
• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Rifampicin

RUO – Research Use Only