RO-3, Tocris Bioscience™

Description

Selective P2X3 and P2X2/3 antagonist

Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

Specifications

• CAS: 1026582-88-6
• Molecular Formula: C16H22N4O2
• Quantity: 10 mg
• Synonym: ro-3, ro3, 5-4,5-dimethoxy-2-methylethyl phenyl methyl-2,4-pyrimidinediamine, d0g8ni, 5-4,5-dimethoxy-2-propan-2-yl phenyl methyl pyrimidine-2,4-diamine
• InChI Key: PYNPWUIBJMVRIG-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC(=C(C=C1CC2=CN=C(N=C2N)N)OC)OC
• IUPAC Name: 5-[(4,5-dimethoxy-2-propan-2-ylphenyl)methyl]pyrimidine-2,4-diamine
• Molecular Weight (g/mol): 302.378
• PubChem CID: 11289644
• Formula Weight: 302.37
• Percent Purity: >98%
• Chemical Name or Material: RO-3