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RO-3, Tocris Bioscience™
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Quantity:
10 mg
Description
Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.
Specifications
Specifications
CAS | 1026582-88-6 |
Molecular Formula | C16H22N4O2 |
Quantity | 10 mg |
Synonym | ro-3, ro3, 5-4,5-dimethoxy-2-methylethyl phenyl methyl-2,4-pyrimidinediamine, d0g8ni, 5-4,5-dimethoxy-2-propan-2-yl phenyl methyl pyrimidine-2,4-diamine |
InChI Key | PYNPWUIBJMVRIG-UHFFFAOYSA-N |
SMILES | CC(C)C1=CC(=C(C=C1CC2=CN=C(N=C2N)N)OC)OC |
IUPAC Name | 5-[(4,5-dimethoxy-2-propan-2-ylphenyl)methyl]pyrimidine-2,4-diamine |
Molecular Weight (g/mol) | 302.378 |
PubChem CID | 11289644 |
Formula Weight | 302.37 |
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