Ro 32-0432 hydrochloride, Tocris Bioscience™

Description

Potent, orally active PKC inhibitor

Selective cell-permeable protein kinase C inhibitor. Displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Orally available and prevents T cell chronic inflammation in vivo.

Specifications

• CAS: 1781828-85-0
• Molecular Formula: C28H29ClN4O2
• Quantity: 1 mg
• Synonym: ro 32-0432 hydrochloride
• InChI Key: HSPRASOZRZDELU-UNTBIKODSA-N
• SMILES: CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl
• IUPAC Name: 3-[(8R)-8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;hydrochloride
• Molecular Weight (g/mol): 489.016
• PubChem CID: 124081018
• Formula Weight: 489.01
• Percent Purity: >99%
• Chemical Name or Material: Ro 32-0432 hydrochloride