Rotenone, Tocris Bioscience™

Description

Inhibits complex I of the mitochondrial electron transport chain

Mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.

Specifications

• CAS: 83-79-4
• Molecular Formula: C23H22O6
• Quantity: 50 mg
• Synonym: rotenone, dactinol, paraderil, --rotenone, tubatoxin, barbasco, --cis-rotenone, derrin, derris, cube root
• InChI Key: JUVIOZPCNVVQFO-HBGVWJBISA-N
• SMILES: CC(=C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC
• Molecular Weight (g/mol): 394.423
• PubChem CID: 6758
• ChEBI: CHEBI:28201
• Formula Weight: 394.42
• Percent Purity: >95%
• Chemical Name or Material: Rotenone