Tocris Bioscience™ RU.521

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Brand:  Tocris Bioscience™ 7904/10

Product Code. 18736205

Description

RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 μM and 2.94 μM against m-cGAS and h-cGAS, respectively). RU.521 suppresses dsDNA-activated reporter activity but not 5'ppp-HP20 RNA or murine IFN-β-induced IFN-β1-dependent gene expression. RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Gouti?res syndrome. Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.

Specifications

• Chemical Name or Material: 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
• Quantity: 10 mg
• Molecular Formula: C₁₉H₁₂Cl₂N₄O₃

• CAS: 2262452-06-0
• Target: Synthase/Synthetase Inhibitors
• Purity: 0.98