(S)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11383596	Thermo Scientific Alfa Aesar L14583.XF	1 mL
11393596	Thermo Scientific Alfa Aesar L14583.AA	5 mL
11303606	Thermo Scientific Alfa Aesar L14583.AC	25 mL

Description

(S)-2-Methyl-CBS-oxazaborolidine is used as an oxazaborolidine catalyst. It is also employed in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols and propargyl alcohols. It is an anhydrous catalyst for CBS reduction reaction.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
(S)-2-Methyl-CBS-oxazaborolidine is used as an oxazaborolidine catalyst. It is also employed in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols and propargyl alcohols. It is an anhydrous catalyst for ′CBS′ reduction reaction.

Solubility
Hydrolyzes in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Incompatible with oxidizing agents.

Chemical Identifiers

• CAS: 112022-81-8
• Molecular Weight (g/mol): 277.17
• InChI Key: VMKAFJQFKBASMU-KRWDZBQOSA-N
• PubChem CID: 2734713
• SMILES: [H][C@@]12CCCN1B(C)OC2(C1=CC=CC=C1)C1=CC=CC=C1

• Molecular Formula: C18H20BNO
• MDL Number: MFCD00078439
• Synonym: s-2-methyl-cbs-oxazaborolidine, s-methyl oxazaborolidine, s---2-methyl-cbs-oxazaborolidine, s-5,5-diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine, corey catalyst, s-methyl-cbs-oxazaborolidine, s-3,3-diphenyl-1-methylpyrrolidino 1,2-c-1,3,2-oxazaborole, s-me-cbs catalyst, s-methyl-cbs, s-me-cbs
• IUPAC Name: (3aS)-1-methyl-3,3-diphenyl-3a,4,5,6-tetrahydropyrrolo[1,2-c][1,3,2]oxazaborole

Specifications

• CAS: 112022-81-8
• Flash Point: 4°C (39°F)
• MDL Number: MFCD00078439
• Sensitivity: Air and moisture sensitive
• Solubility Information: Hydrolyzes in water.
• SMILES: [H][C@@]12CCCN1B(C)OC2(C1=CC=CC=C1)C1=CC=CC=C1
• Molecular Weight (g/mol): 277.17
• Formula Weight: 277.17
• Chemical Name or Material: (S)-2-Methyl-CBS-oxazaborolidine

• Density: 0.925
• Molecular Formula: C18H20BNO
• UN Number: UN1993
• Synonym: s-2-methyl-cbs-oxazaborolidine, s-methyl oxazaborolidine, s---2-methyl-cbs-oxazaborolidine, s-5,5-diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine, corey catalyst, s-methyl-cbs-oxazaborolidine, s-3,3-diphenyl-1-methylpyrrolidino 1,2-c-1,3,2-oxazaborole, s-me-cbs catalyst, s-methyl-cbs, s-me-cbs
• InChI Key: VMKAFJQFKBASMU-KRWDZBQOSA-N
• IUPAC Name: (3aS)-1-methyl-3,3-diphenyl-3a,4,5,6-tetrahydropyrrolo[1,2-c][1,3,2]oxazaborole
• PubChem CID: 2734713
• Concentration or Composition (by Analyte or Components): 1M soln. in toluene

Safety and Handling

GHS H Statement
H224-H304-H361-H373-H332-H315-H336
Extremely flammable liquid and vapor.
May be fatal if swallowed and enters airways.
Suspected of damaging fertility or the unborn child.
May cause damage to organs through prolonged or repeated exposure.
Harmful if inhaled.
Causes skin irritation.
May cause drowsiness or dizziness.

P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P281-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P310-P330-P331-P332+P313-P363-P370+P378q-P50

H225-H302-H304-H315-H318-H335-H336-H361d-H372

missing translation for 'dotInformation' : Transport Hazard Class: 3; Packing Group: II; Proper Shipping Name: FLAMMABLE LIQUIDS, N.O.S.

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only