(S)-Duloxetine hydrochloride, Tocris Bioscience™

Description

Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Ki values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

Specifications

Chemical Identifiers

• CAS: 136434-34-9
• Molecular Formula: C18H20ClNOS
• Molecular Weight (g/mol): 333.87
• MDL Number: MFCD06407958,MFCD06801358
• InChI Key: BFFSMCNJSOPUAY-LMOVPXPDSA-N
• Synonym: (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride
• PubChem CID: 87834970
• IUPAC Name: hydrogen methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine chloride
• SMILES: [H+].[Cl-].CNCC[C@H](OC1=C2C=CC=CC2=CC=C1)C1=CC=CS1

• Quantity: 50 mg
• Formula Weight: 333.88
• Percent Purity: >99%
• Chemical Name or Material: (S)-Duloxetine hydrochloride