SAHA, Tocris Bioscience™

Description

Class I and II HDAC inhibitor

SAHA inhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro. Activates autophagy. SAHA increases efficiency of transcription factor-induced reprogramming of mouse embryonic fibroblasts (MEF) to induced pluripotent stem cells (iPSC). Also enhances adeno-associated virus transduction of HeLa cells.

Specifications

Chemical Identifiers

• CAS: 149647-78-9
• Molecular Formula: C14H20N2O3
• Molecular Weight (g/mol): 264.325
• InChI Key: WAEXFXRVDQXREF-UHFFFAOYSA-N
• Synonym: vorinostat, saha, suberoylanilide hydroxamic acid, zolinza, n-hydroxy-n'-phenyloctanediamide, suberanilohydroxamic acid, n1-hydroxy-n8-phenyloctanediamide, saha cpd, vorinostat usan, octanediamide, n-hydroxy-n'-phenyl
• PubChem CID: 5311
• ChEBI: CHEBI:45716
• IUPAC Name: N'-hydroxy-N-phenyloctanediamide
• SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

• Quantity: 10 mg
• Formula Weight: 264.32
• Percent Purity: >98%
• Chemical Name or Material: SAHA