SANT-1, Tocris Bioscience™

Description

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic β cells from hPSCs.

For more information about how SANT-1 may be used, see our protocol:

Generation of β cells from hPSCs

Specifications

Chemical Identifiers

• CAS: 304909-07-7
• Molecular Formula: C23H27N5
• Molecular Weight (g/mol): 373.50
• MDL Number: MFCD01827306
• InChI Key: FOORCIAZMIWALX-UHFFFAOYSA-N
• Synonym: sant-1, shh signaling antagonist v, 4-benzyl-piperazin-1-yl-3,5-dimethyl-1-phenyl-1h-pyrazol-4-ylmethylene-amine, e-4-benzyl-n-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylene piperazin-1-amine, n-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylene-4-phenylmethyl-1-piperazinamine, n-4-benzylpiperazin-1-yl-1-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methanimine, e-n-4-benzylpiperazin-1-yl-1-3,5-dimethyl-1-phenylpyrazol-4-yl methanimine, 4-benzyl-n-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylene piperazin-1-amine, 4-benzyl-n-e-3,5-dimethyl-1-phenyl-1h-pyrazol-4-yl methylidene piperazin-1-amine
• PubChem CID: 6878030
• IUPAC Name: N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
• SMILES: CC1=NN(C(C)=C1C=NN1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1

• Quantity: 10 mg
• Formula Weight: 373.5
• Percent Purity: >99%
• Chemical Name or Material: SANT-1