SAR 7334

Potent TRPC6 inhibitor

Brand:  Tocris 5831/5

Product Code. 18740809

Description

SAR 7334 is a potent TRPC6 inhibitor (IC50 values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca2+ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.

Specifications

• Chemical Name or Material: 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
• Assay Percent Range: >98%
• Molecular Formula: C₂₁H₂₂ClN₃O.2HCl

• CAS: 1333207-63-8
• Quantity: 5 mg
• Formula Weight: Observed MW: 440.79