Sarcomeric alpha Actin Monoclonal Antibody (5C5), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA126928

Product Code. 11529562

Description

This antibody is specific to alpha-skeletal and alpha-cardiac muscle actins. It does not react with smooth muscle tissue.

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.

Specifications

• Antigen: Sarcomeric alpha Actin
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ACTA2
• Gene Alias: 0610041G09Rik; AA959943; AAT6; act; ACT-4; ACTA; acta1; ACTA1 protein; Acta2; Acta-2; ACTC; actc1; Actc-1; actc1.L; actg; actin; Actin alpha 1; actin alpha 1, skeletal muscle; actin alpha 2, smooth muscle; actin alpha cardiac; actin alpha cardiac 1; actin alpha cardiac muscle 1; actin, alpha 1, skeletal muscle; actin, alpha 2, smooth muscle, aorta; actin, alpha cardiac muscle 1; Actin, alpha cardiac muscle 1, intermediate form; Actin, alpha skeletal muscle; Actin, alpha skeletal muscle, intermediate form; actin, alpha, cardiac 1; actin, alpha, cardiac muscle; actin, alpha, cardiac muscle 1; actin, alpha, cardiac muscle 1 L homeolog; actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; actna1; Acts; ACTSA; Actsk-1; ACTVS; alpha actin; alpha actin 1; alpha actin 2; alpha-actin cardiac; Alpha-actin-1; Alpha-actin-2; alphac-actin; alpha-cardiac actin; alphaSMA; alpha-sma; alpha-smooth muscle actin; ASD5; ASMA; a-SMA; B-actin; be
• Host Species: Mouse
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Rabbit
• Product Type: Antibody
• Isotype: IgM

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
• Clone: 5C5
• Formulation: ascites with 0.09% sodium azide
• Gene Accession No.: P62736, P62740, P68032, P68133, P68135
• Gene Symbols: ACTA1, ACTA2, ACTC1
• Immunogen: Purified rabbit striated muscle actin.
• Regulatory Status: RUO
• Gene ID (Entrez): 100009271, 100009506, 100340339, 58, 59, 70
• Content And Storage: 4° C
• Form: Liquid