SB 202190, Tocris Bioscience™

Description

Potent, selective inhibitor of p38 MAPK

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.

Specifications

Chemical Identifiers

• CAS: 152121-30-7
• Molecular Formula: C20H14FN3O
• Molecular Weight (g/mol): 331.35
• MDL Number: MFCD00941964
• InChI Key: NJNKPVPFGLGHPA-UHFFFAOYSA-N
• Synonym: fhpi, unii-pvx798p8gi, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl imidazole, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl-1h-imidazole, pvx798p8gi, sb 202190, immobilized, insolution sb 202190, 4-4-4-fluorophenyl-5-pyridin-4-yl-1h-imidazol-2-yl phenol, phenol, 4-4-4-fluorophenyl-5-4-pyridinyl-1h-imidazol-2-yl
• PubChem CID: 5353940
• IUPAC Name: 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-imidazol-2-ylidene]cyclohexa-2,5-dien-1-one
• SMILES: FC1=CC=C(C=C1)C1=C(NC(N1)=C1C=CC(=O)C=C1)C1=CC=NC=C1

• Quantity: 10 mg
• Formula Weight: 331.35
• Percent Purity: >99%
• Chemical Name or Material: SB 202190