SB 225002, Tocris Bioscience™

Description

Potent and selective CXCR2 antagonist

Potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GROα-mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo. Inhibits HIV replication in lymphocytes and macrophages.

Specifications

Chemical Identifiers

• CAS: 182498-32-4
• Molecular Formula: C13H10BrN3O4
• Molecular Weight (g/mol): 352.14
• MDL Number: MFCD00954637
• InChI Key: MQBZVUNNWUIPMK-UHFFFAOYSA-N
• Synonym: 1-2-bromophenyl-3-2-hydroxy-4-nitrophenyl urea, n-2-bromophenyl-n'-2-hydroxy-4-nitrophenyl urea, 3-2-bromophenyl-1-2-hydroxy-4-nitrophenyl urea, n-2-hydroxy-4-nitrophenyl-n′-2-bromophenyl urea, d0e9bu, d0f6wv, d0t2ad, gtpl833, n-2-hydroxy-4-nitrophenyl-n'-2-bromophenyl urea, p 1-6-hydroxymethylpterin-p 2-5'-adenosyl diphosphate
• PubChem CID: 3854666
• IUPAC Name: 3-(2-bromophenyl)-1-(2-hydroxy-4-nitrophenyl)urea
• SMILES: OC1=C(NC(=O)NC2=CC=CC=C2Br)C=CC(=C1)[N+]([O-])=O

• Quantity: 50 mg
• Formula Weight: 352.14
• Percent Purity: >99%
• Chemical Name or Material: SB 225002