SB 415286, Tocris Bioscience™

Description

Potent, selective GSK-3 inhibitor

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Specifications

Chemical Identifiers

• CAS: 264218-23-7
• Molecular Formula: C16H10ClN3O5
• Molecular Weight (g/mol): 359.722
• InChI Key: PQCXVIPXISBFPN-UHFFFAOYSA-N
• Synonym: 3-3-chloro-4-hydroxyphenylamino-4-2-nitrophenyl-1h-pyrrole-2,5-dione, 3-3-chloro-4-hydroxyphenylamino-4-4-nitrophenyl-1h-pyrrole-2,5-dione, 3-3-chloro-4-hydroxyphenyl amino-4-2-nitrophenyl-1h-pyrrole-2,5-dione, 3-3-chloro-4-hydroxyanilino-4-2-nitrophenyl pyrrole-2,5-dione, 1h-pyrrol-2,5-dione, 3-3-chloro-4-hydroxyphenyl amino-4-2-nitrophenyl, tocris-1617, lopac-s-3567, d0n4wb, sb hplc
• PubChem CID: 4210951
• IUPAC Name: 3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)pyrrole-2,5-dione
• SMILES: C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

• Quantity: 10 mg
• Formula Weight: 359.73
• Percent Purity: >99%
• Chemical Name or Material: SB 415286