SC 26196, Tocris Bioscience™

Description

Selective fatty acid desaturase 2 inhibitor

Selective fatty acid desaturase 2 (FADS2, also known as Δ6 desaturase) inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ5 desaturase and SCD-1/Δ9 desaturase, respectively) (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.

Specifications

Chemical Identifiers

• CAS: 218136-59-5
• Molecular Formula: C27H29N5
• Molecular Weight (g/mol): 423.564
• InChI Key: QFYKXKMYVYOUNJ-UHFFFAOYSA-N
• Synonym: α, α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
• PubChem CID: 71752132
• IUPAC Name: 2,2-diphenyl-5-[4-(pyridin-3-ylmethylideneamino)piperazin-1-yl]pentanenitrile
• SMILES: C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4

• Quantity: 10 mg
• Formula Weight: 423.55
• Percent Purity: >98%
• Chemical Name or Material: SC 26196