SDHB Monoclonal Antibody (CL0349), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA531350

Product Code. 16374794

Description

Immunogen sequence: EGKQQYLQSI EEREKLDGLY ECILCACCST SCPSYWWNGD KYLGPAVLMQ AYRWMIDSRD DFTEERLAKL QDPFSLYRCH TIMNCTRTCP KGLNPGKAIA EIKKMMATY

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Specifications

• Antigen: SDHB
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P21912
• Gene Symbols: Sdhb
• Immunogen: Recombinant protein corresponding to Human SDHB
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Clone: CL0349
• Conjugate: Unconjugated
• Gene: Sdhb
• Gene Alias: 0710008N11Rik; CWS2; fj46d06; FLJ92337; I79_022285; Ip; iron-sulfur subunit; iron-sulfur subunit of complex II; OTTHUMP00000044624; PGL4; SDH; SDH1; SDH2; Sdhb; SDHB protein; SDHB; sdhB; SDHIP; succinate dehydrogenase [ubiquinone] iron-sulfur subunit; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex iron sulfur subunit B; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex subunit B, iron sulfur (Ip); succinate dehydrogenase complex, subunit B, iron sulfur (Ip); succinate dehydrogenase Ip subunit; succinate dehydrogenase iron-protein subunit; wu:fj46d06
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 6390
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid