Tocris Bioscience™ Selinexor

Selective exportin 1 (XPO1/CRM1) inhibitor

Brand:  Tocris Bioscience™ 7760/10

Product Code. 18737176

Description

Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.

Specifications

• Chemical Name or Material: (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
• Quantity: 10 mg
• Molecular Formula: C₁₇H₁₁F₆N₇O

• CAS: 1393477-72-9
• Target: Antiviral Compounds