Sivelestat sodium salt, Tocris Bioscience™

Description

Selective leukocyte elastase inhibitor

Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Specifications

Chemical Identifiers

• CAS: 150374-95-1
• Molecular Formula: C20H21N2NaO7S
• Molecular Weight (g/mol): 456.445
• InChI Key: ZAIFANJZUGNYCK-UHFFFAOYSA-M
• Synonym: sivelestat sodium, sivelestat sodium salt, unii-0cll4232kd, sivelestat sodium salt hydrate, ono-5046.na, sivelestat sodium anhydrous, sivelestatsodium, c20h21n2o7s.na, glycine, n-2-4-2,2-dimethyl-1-oxopropoxy phenyl sulfonyl amino benzoyl-, monosodium salt
• PubChem CID: 23664980
• IUPAC Name: sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate
• SMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]

• Quantity: 50 mg
• Formula Weight: 456.44
• Percent Purity: >98%
• Chemical Name or Material: Sivelestat sodium salt