SMER 28, Tocris Bioscience™

Description

Positive regulator of autophagy

Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Specifications

Chemical Identifiers

• CAS: 307538-42-7
• Molecular Formula: C11H10BrN3
• Molecular Weight (g/mol): 264.13
• MDL Number: MFCD02166825
• InChI Key: BCPOLXUSCUFDGE-UHFFFAOYSA-N
• PubChem CID: 1560402
• IUPAC Name: 6-bromo-N-(prop-2-en-1-yl)quinazolin-4-amine
• SMILES: BrC1=CC2=C(NCC=C)N=CN=C2C=C1

• Quantity: 10 mg
• Synonym: smer28, smer 28, n-allyl-6-bromoquinazolin-4-amine, 6-bromo-n-2-propenyl-4-quinazolinamine, 6-bromo-n-prop-2-en-1-yl quinazolin-4-amine, 3srb, cbmicro_021891, smer26, cambridge id 6164173, smer28 2
• Formula Weight: 264.12
• Percent Purity: >99%
• Chemical Name or Material: SMER 28