SMO Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16810365	Proteintech 20787-1-AP-20UL	20 μL
16800365	Proteintech 20787-1-AP-150UL	150 μL

Description

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

Specifications

• Antigen: SMO
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q99835
• Gene ID (Entrez): 6608
• Immunogen: SMO Fusion Protein Ag14322
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SMO

• Concentration: 0.44 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: Gx, Protein Gx, SMO, SMOH, Smoothened homolog
• Gene Symbols: SMO
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody