SR 142948, Tocris Bioscience™

Description

Highly potent NTS receptor antagonist

Potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.

Specifications

Chemical Identifiers

• CAS: 184162-64-9
• Molecular Formula: C39H51N5O6
• Molecular Weight (g/mol): 685.866
• InChI Key: LWULHXVBLMWCHO-UHFFFAOYSA-N
• Synonym: d0oj7s, sr 142948 hydrochloride, 2-5-2,6-dimethoxyphenyl-1-4-3-dimethylamino propyl methylamino carbonyl-2-1-methylethyl phenyl-1h-pyrazol-3-yl carbonyl amino-tricyclo 3.3.1.13,7 decane-2-carboxylic acid, 2-5-2,6-dimethoxyphenyl-1-4-n-3-dimethylaminopropyl-n-methylcarbamoyl-2-isopropylphenyl-1h-pyrazole3-carbonyl amino adamantane-2-carboxylic acid hydrochloride, 2-5-2,6-dimethoxyphenyl-1-4-3-dimethylaminopropyl-methylcarbamoyl-2-propan-2-ylphenyl pyrazole-3-carbonyl amino adamantane-2-carboxylic acid, 2-5-2,6-dimethoxyphenyl-1-4-3-dimethylamino propyl-methylcarbamoyl-2-propan-2-ylphenyl pyrazole-3-carbonyl amino adamantane-2-carboxylic acid, 2-5-2,6-dimethoxyphenyl-1-4-3-dimethylamino propyl methyl carbamoyl-2-isopropylphenyl pyrazole-3-amido adamantane-2-carboxylic acid, 2-5-2,6-dimethoxyphenyl-1-4-n-methyl-n-3-dimethylaminopropyl carbamoyl-2-isopropylphenyl-3-pyrazolylcarbonylamino-2-adamantanecarboxylic acid
• PubChem CID: 5311451
• IUPAC Name: 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methylcarbamoyl]-2-propan-2-ylphenyl]pyrazole-3-carbonyl]amino]adamantane-2-carboxylic acid
• SMILES: CC(C)C1=C(C=CC(=C1)C(=O)N(C)CCCN(C)C)N2C(=CC(=N2)C(=O)NC3(C4CC5CC(C4)CC3C5)C(=O)O)C6=C(C=CC=C6OC)OC

• Quantity: 1 mg
• Formula Weight: 685.86
• Percent Purity: >97%
• Chemical Name or Material: SR 142948