SR 2211, Tocris Bioscience™

Description

Selective RORγ inverse agonist

Selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ∽320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Specifications

Chemical Identifiers

• CAS: 1359164-11-6
• Molecular Formula: C26H24F7N3O
• Molecular Weight (g/mol): 527.487
• InChI Key: KVHKWAZUPPBMLL-UHFFFAOYSA-N
• Synonym: 2-fluoro-4'-4-4-pyridinylmethyl-1-piperazinyl methyl-, a,, a-bis trifluoromethyl-1,1'-biphenyl-4-methanol, 1,1,1,3,3,3-hexafluoro-2-2-fluoro-4'-4-pyridin-4-ylmethyl piperazin-1-yl methyl-1,1'-biphenyl-4-yl propan-2-ol, 2-fluoro-4'-4-4-pyridinylmethyl-1-piperazinyl methyl-a,a-bis trifluoromethyl-1,1'-biphenyl-4-methanol
• PubChem CID: 51035449
• IUPAC Name: 1,1,1,3,3,3-hexafluoro-2-[3-fluoro-4-[4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol
• SMILES: C1CN(CCN1CC2=CC=C(C=C2)C3=C(C=C(C=C3)C(C(F)(F)F)(C(F)(F)F)O)F)CC4=CC=NC=C4

• Quantity: 10 mg
• Formula Weight: 527.48
• Percent Purity: >98%
• Chemical Name or Material: SR 2211