SREBF1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16852574	Proteintech 14088-1-AP-20UL	20 μL
16842574	Proteintech 14088-1-AP-150UL	150 μL

Description

This antibody can recognize the 125 kDa precursor form and the 68 kDa mature form of human SREBF1.

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins. Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function. SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment. In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes. While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.

Specifications

• Antigen: SREBF1
• Applications: Immunoprecipitation, Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P36956
• Gene ID (Entrez): 6720
• Immunogen: SREBF1 Fusion Protein Ag5219
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: SREBF1

• Concentration: 0.54 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: bHLHd1, SREBF1, SREBP 1, SREBP 1c, SREBP1
• Gene Symbols: SREBF1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody