SSR 69071, Tocris Bioscience™

Description

Potent, orally active human leukocyte elastase inhibitor

High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.

Specifications

• CAS: 344930-95-6
• Molecular Formula: C27H32N4O7S
• Quantity: 10 mg
• Synonym: d0b3mv, dsstox_cid_27368, dsstox_rid_82301, dsstox_gsid_47368, 2-6-methoxy-4-1-methylethyl-1,1-dioxido-3-oxo-1,2-benzisothiazol-2 3h-yl methoxy-9-2-1-piperidinyl ethoxy-4h-pyrido 1,2-a pyrimidin-4-one, 2-6-methoxy-1,1-dioxido-3-oxo-4-propan-2-yl-1,2-benzothiazol-2 3h-yl methoxy-9-2-piperidin-1-yl ethoxy-4h-py...
• InChI Key: DRZXDZYWZSKFDL-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC(=CC2=C1C(=O)N(S2(=O)=O)COC3=CC(=O)N4C=CC=C(C4=N3)OCCN5CCCCC5)OC
• IUPAC Name: 6-methoxy-1,1-dioxo-2-[[4-oxo-9-(2-piperidin-1-ylethoxy)pyrido[1,2-a]pyrimidin-2-yl]oxymethyl]-4-propan-2-yl-1,2-benzothiazol-3-one
• Molecular Weight (g/mol): 556.634
• PubChem CID: 9872438
• Formula Weight: 556.63
• Percent Purity: >98%
• Chemical Name or Material: SSR 69071