ST 034307, Tocris Bioscience™

Description

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Specifications

Chemical Identifiers

• CAS: 133406-29-8
• Molecular Formula: C10H4Cl4O2
• Molecular Weight (g/mol): 297.94
• InChI Key: NTDHYMSVCBGQJF-UHFFFAOYSA-N
• Synonym: ST 034307
• PubChem CID: 867466
• IUPAC Name: 6-chloro-2-(trichloromethyl)chromen-4-one
• SMILES: C1=CC2=C(C=C1Cl)C(=O)C=C(O2)C(Cl)(Cl)Cl

• Linear Formula: C₁₀H₄Cl₄O₂
• Quantity: 50 mg
• Solubility Information: Soluble to 100mM in DMSO and to 20mM in ethanol
• Formula Weight: 297.95
• Percent Purity: >98%
• Physical Form: Solid
• Chemical Name or Material: 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one