STRO-1 Monoclonal Antibody (STRO-1), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen 398401

Product Code. 10706663

Description

STRO-1 is a cell surface antigen expressed by stromal elements in human bone marrow. STRO-1 binds to approximately 10% of bone marrow mononuclear cells, greater than 95% of which are nucleated erythroid precursors, but does not react with committed progenitor cells (colony-forming unit granulocyte-macrophage (CFU-GM), erythroid bursts (BFU-E), and mixed colonies (CFU-Mix). From bone marrow cells, the frequency of fibroblast colony forming cells (CFU-F) is enriched approximately 100-fold in the STRO-1-positive/Glycophorin A-negative population than in the STRO-1-positive/Glycophorin A-positive population. When plated under long-term BM culture conditions, STRO-1-positive cells generate adherent cell layers containing multiple stromal cell types, including adipocytes, smooth muscle cells, and fibroblastic elements. A STRO-1-positive enriched subset of marrow cells is capable of differentiating into multiple mesenchymal lineages including hematopoiesis-supportive stromal cells with a vascular smooth muscle-like phenotype, adipocytes, osteoblasts and chondrocytes. STRO-1 is a valuable antibody for the identification, isolation and functional characterization of human bone marrow stromal cell precursors.

Specifications

• Antigen: STRO-1
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.1% sodium azide
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Western Blot
• Clone: STRO-1
• Conjugate: Unconjugated
• Gene Alias: STRO1
• Immunogen: CD34+ human bone marrow cells
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgM