SU 6668, Tocris Bioscience™

Description

PDGFR, VEGFR and FGFR inhibitor

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

Specifications

Chemical Identifiers

• CAS: 252916-29-3
• Molecular Formula: C18H18N2O3
• Molecular Weight (g/mol): 310.353
• InChI Key: NHFDRBXTEDBWCZ-NTEUORMPSA-N
• Synonym: 3-2,4-dimethyl-5-e-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, e-3-2,4-dimethyl-5-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, tsu 68, tsu-68 su6668,orantinib, 3-2,4-dimethyl-5-3e-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 3-2,4-dimethyl-5-e-2-oxo-1,2-dihydro-3h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, tsu-68 random configuration, z-3-2,4-dimethyl-5-2-oxoindolin-3-ylidene-methyl-1h-pyrrol-3-yl propanoic acid, 3-2,4-dimethyl-5-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 5-1,2-dihydro-2-oxo-3h-indol-3-ylidene methyl-2,4-dimethyl-1h-pyrrole-3-propanoic acid
• PubChem CID: 5995546
• IUPAC Name: 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
• SMILES: CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O

• Quantity: 10 mg
• Formula Weight: 310.35
• Percent Purity: >99%
• Chemical Name or Material: SU 6668