Thermo Scientific Chemicals Sulindac Sulfide

Description

 

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

• Quantity: 100 mg
• Description: Yellow
• For Use With (Application): Active metabolite of sulindac; inhibits cyclooxygenase-1
• CAS: 32004-67-4
• Molecular Formula: C₂₀H₁₇FO₂S, C20H17FO2S
• Formula Weight: 340.41g/mol
• Melting Point: 189°C to 191°C
• Solubility: Soluble in DMSO
• Product Type: Signal Transduction Reagent
• Form: Powder
• MDL Number: MFCD00869764
• InChI Key: LFWHFZJPXXOYNR-RQZCQDPDSA-N
• SMILES: CSC1=CC=C(\C=C2/C(C)=C(CC(O)=O)C3=CC(F)=CC=C23)C=C1
• IUPAC Name: 2-[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfanyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
• Molecular Weight (g/mol): 340.41

Safety and Handling

Product Identifier

• Sulindac sulfide

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 3
• Reproductive toxicity on or via lactation
• Reproductive toxicity Category 2
• Respiratory sensitiser Category 1
• Skin sensitiser Category 1
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H301-Toxic if swallowed.
• H317-May cause an allergic skin reaction.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
• H361-Suspected of damaging fertility or the unborn child.
• H362-May cause harm to breast-fed children.
• H373-May cause damage to organs.

Precautionary Statement

• P201-Obtain special instructions before use.
• P263-Avoid contact during pregnancy/while nursing.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P284-¢In case of inadequate ventilation! wear respiratory protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .

Supplemental information

• MIXTURE LIST-Contains : Sulindac sulfide

RUO – Research Use Only