Tocris Bioscience™ TBK1 PROTAC™ 3i

Potent TANK-binding kinase 1 (TBK1) PROTAC™

Brand:  Tocris Bioscience™ 7259/5

Product Code. 18054992

Description

TBK1 PROTAC® 3i is a potent TANK-binding kinase 1 (TBK1) PROTAC™ Degrader (DC50 = 12 nM, Dmax = 96%). Exhibits >50-fold selectivity for TBK1 over the closely related IKKε. Comprises a ligand for von-Hippel Lindau (VHL) protein joined by a linker to a TBK1-targeting moiety. Brings about near complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines with no significant effect of proliferation.

Negative control TBK1 control PROTAC® 4 (Cat. No. 7260) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

• Chemical Name or Material: (2 S,4 R)-1-(-18-(4-((5-Bromo-4-((3-(N-methylcyclobutanecarboxamido)propyl)amino)pyrimidin-2-yl)amino)phenoxy)-2-(tert-butyl)-4-oxo-6,10,15-trioxa-3-azaoctadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
• Quantity: 5 mg
• Molecular Formula: C₅₃H₇₄BrN₉O₉S

• CAS: 2052306-13-3
• Target: Active Degraders
• Purity: 0.98