TCS ERK 11e, Tocris Bioscience™

Description

Potent and selective ERK2 inhibitor

Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

Specifications

• CAS: 896720-20-0
• Molecular Formula: C24H20Cl2FN5O2
• Quantity: 10 mg
• Synonym: vx-11e, vtx-11e, vx 11e, 4-2-2-chloro-4-fluorophenyl amino-5-methylpyrimidin-4-yl-n-1s-1-3-chlorophenyl-2-hydroxyethyl-1h-pyrrole-2-carboxamide, vertex-11e, pyrimidylpyrrole, 11e, tcs erk 11e, vx-11e tcs erk 11e, 4-2-2-chloro-4-fluoroanilino-5-methylpyrimidin-4-yl-n-1s-1-3-chlorophenyl-2-hydroxyethyl-1h-pyrrole-2-carboxamide, 4-2-2-chloro-4-fluorophenyl amin-o-5-methyl-4-pyrimidinyl-n-1s-1-3-chlorophen-yl-2-hydroxyethyl-1h-pyrrole-2-carboxamide
• InChI Key: WUTVMXLIGHTZJC-OAQYLSRUSA-N
• SMILES: CC1=CN=C(N=C1C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl
• IUPAC Name: 4-[2-(2-chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
• Molecular Weight (g/mol): 500.355
• PubChem CID: 11634725
• Formula Weight: 500.35
• Percent Purity: >98%
• Chemical Name or Material: TCS ERK 11e