TDP-43 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10782-2-AP-20UL

Product Code. 16857393

Description

Proteintech's 10782-2-AP antibody is a rabbit polyclonal antibody recognizing N-terminal TDP-43. It recognizes the intact 45 kDa protein as well as all post translationally modified and truncated forms in multiple applications. Various forms of TDP-

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

Specifications

• Antigen: TDP-43
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TARDBP
• Gene Alias: ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 230908, 23435, 298648, 325052
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Immunohistochemistry, Flow Cytometry
• Concentration: 0.31 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q13148, Q921F2
• Gene Symbols: tardbp
• Immunogen: TDP-43 Fusion Protein Ag1231
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Rat, Zebrafish, Mouse, Human
• Product Type: Antibody
• Isotype: IgG