Tocris Bioscience™ Temsirolimus

mTOR inhibitor; antitumor

Brand:  Tocris Bioscience™ 5264/10

Product Code. 18775298

Description

Temsirolimus is a mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1α-mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo. Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.

Specifications

• Purity: >98%
• Quantity: 10 mg
• Molecular Weight (g/mol): 1030.29

• Gene Alias: CCI-779
• Product Type: Temsirolimus
• Inhibitors: Temsirolimus

For Research Use Only