Tetracycline, Thermo Scientific Chemicals

Description

Tetracycline, Deschlorobiomycin, CAS # 60-54-8, is a broad-spectrum napthacene antibiotic that inhibits bacterial growth.

Tetracycline is used for treatment of chronic inflammatory cells. Tetracycline derivatives induce apoptosis in osteoclasts, Jurkat T lymphocyte cells and in cultured monocytes and macrophages. It is a compound that has been shown to induce apoptosis in various cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Tetracycline is a semisynthetic compound derived from chlortetracycline, an isolate from Streptomyces aureofaciens
• Tetracycline is a broad-spectrum bacteriostatic that inhibits polypeptide formation by binding the 30S ribosomal subunit and preventing aminoacyl tRNA-mRNA complex formation
• It may have other bactericidal properties such as limited binding to the 50S subunit

Application

• Tetracycline has been shown to exhibit antiprotozoal properties
• It can be used to kill both gram-positive and gram-negative bacteria
• It is suitable for use in laboratory applications in resistance gene testing and research on infection

Specifications

Chemical Identifiers

• CAS: 60-54-8
• Molecular Formula: C22H24N2O8
• Molecular Weight (g/mol): 444.44
• MDL Number: MFCD00151232
• InChI Key: JYHCQVWYCGHXGP-BPPSBWQWSA-N
• PubChem CID: 54675776
• SMILES: CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)C4=C(O)C=CC=C4[C@@]3(C)O)C(=O)[C@]2(O)C(=O)\C(=C(\N)O)C1=O

• Type: Tetracycline
• Physical Form: Crystalline Powder
• Melting Point: 172°C to 174°C
• Color: Yellow
• Quantity: 25 g
• Beilstein: 2230417
• Merck Index: 14,9196
• Solubility Information: Limited solubility in water; Soluble in 1M HCl with heating.
• IUPAC Name: (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
• Formula Weight: 444.43
• Chemical Name or Material: Tetracycline

Safety and Handling

Product Identifier

• Tetracycline

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Tetracycline

RUO – Research Use Only