Thimerosal, Thermo Scientific Chemicals

Description

Thimerosal, CAS # 54-64-8, is a sulfhydryl (thiol) oxidizing reagent with antibacterial and antifungal activities that is used to protect components from chemical change or microbial action.

Thimerosal, has been widely used as a preservative in a number of biological and drug products, including many vaccines, to help prevent potentially life threatening contamination with harmful microbes. It has been used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Thimerosal is an organic compound and a derivative of thiosalicyclic acid. It shows antibacterial and antifungal activities and has the ability to protect against chemical change or microbial action

• Thimerosal can inhibit the sulfhydryl-containing active site of some enzymes and bind to sulfhydryl compounds, such as glutathione, cysteine, and thiol groups of proteins

• It can activate the InsP3 calcium channel on the endoplasmic reticular membrane, triggering the release of calcium from intracellular stores, leading to a calcium-influx of extracellular calcium. Thus, thimerosal may stimulate or inhibit cellular functions dependent on calcium signaling

Application

• Thimerosal can increase histamine release and cell-mediated immunity

• It has the ability to inhibit various sulfhydryl-dependent enzymes and proteins, including PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na+/K+-dependent ATPases

Specifications

Chemical Identifiers

• CAS: 54-64-8
• Molecular Formula: C9H9HgNaO2S
• Molecular Weight (g/mol): 404.81
• MDL Number: MFCD00013062
• InChI Key: RTKIYNMVFMVABJ-UHFFFAOYSA-L
• Synonym: thimerosal, thiomersal, thiomersalate, mercurothiolate, sodium merthiolate, sodium ethylmercurithiosalicylate, merthiolate, thimerosalate, thimerosalum, thimersalate
• PubChem CID: 16684434
• ChEBI: CHEBI:9546
• SMILES: [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O

• Melting Point: 234°C to 237°C
• Color: White
• Flash Point: 250°C (482°F)
• Quantity: 10 g
• UN Number: UN2025
• Beilstein: 8169555
• Merck Index: 14,9317
• Solubility Information: Soluble in water or ethanol
• IUPAC Name: sodium [(2-carboxylatophenyl)sulfanyl](ethyl)mercury
• Formula Weight: 404.81
• Physical Form: Powder
• Chemical Name or Material: Thimerosal

Safety and Handling

Product Identifier

• Thimerosal

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Acute toxicity Category 2
• LONG-TERM AQUATIC HAZARD Chronic 1
• ACUTE AQUATIC Acute 1
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H300-Fatal if swallowed.
• H310-Fatal in contact with skin.
• H330-Fatal if inhaled.
• H373-May cause damage to organs.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P262-Do not get in eyes, on skin, or on clothing.
• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P270-Do not eat, drink or smoke when using this product.
• P271-Use only outdoors or in a well-ventilated area.
• P273-Avoid release to the environment.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P284-¢In case of inadequate ventilation! wear respiratory protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P310-Immediately call a POISON CENTER/doctor/.
• P330-Rinse mouth.
• P362+P364-Take off contaminated clothing and wash it before reuse.
• P391-Collect spillage.
• P403+P233-Store in a well-ventilated place. Keep container tightly closed.
• P405-Store locked up.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : Sodium o-(ethylmercurithio)benzoate

RUO – Research Use Only