Thioperamide, Tocris Bioscience™

Description

H3 antagonist; also H4 inverse agonist

Potent histamine H3 and H4 antagonist/inverse agonist. Ki values are 25 and 27 nM for human recombinant H3 and H4 receptors respectively. Blocks eosinophil shape change (IC50 = 1.4 μM) and chemotaxis (IC50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier.

Specifications

Chemical Identifiers

• CAS: 106243-16-7
• Molecular Formula: C19H28N4O4S
• Molecular Weight (g/mol): 408.517
• InChI Key: WUYMIKDBRCCYGE-UHFFFAOYSA-N
• Synonym: 1-piperidinecarbothioamide, n-cyclohexyl-4-1h-imidazol-4-yl-, 2z-2-butenedioate 1:1
• PubChem CID: 53393972
• IUPAC Name: but-2-enedioic acid;N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
• SMILES: C1CCC(CC1)NC(=S)N2CCC(CC2)C3=CN=CN3.C(=CC(=O)O)C(=O)O

• Quantity: 10 mg
• Formula Weight: 292.44
• Percent Purity: >99%
• Chemical Name or Material: Thioperamide