TMPyP4 tosylate, Tocris Bioscience™

Description

Inhibitor of human telomerase

Cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.

Specifications

• CAS: 36951-72-1
• Molecular Formula: C72H66N8O12S4
• Quantity: 50 mg
• Synonym: tmpyp, tmpyp4 tosylate, tmpyp tetratosylate, tmpyp4 tetratosylate, tppt 4, meso-tetra 4-n-methyl-pyridyl porphyrin, meso-tetrakis n-methyl-4-pyridyl porphine tetratosylate salt, meso-tetrakis n-methylpyridinium-4-yl porphine tetratosylate, meso-tetrakis n-methyl-4-pyridyl porphine tetrakis p-toluenesulfonate, 5,10,15,20-tetrakis 1-methylpyridinium-4-yl porphyrin tetra p-toluenesulfonate
• InChI Key: AKZFRMNXBLFDNN-UHFFFAOYSA-K
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=CC=C(N4)C(=C5C=CC(=N5)C(=C6C=CC2=N6)C7=CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C9=CC=[N+](C=C9)C)N3
• IUPAC Name: 4-methylbenzenesulfonate;5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,22-dihydroporphyrin
• Molecular Weight (g/mol): 1363.604
• PubChem CID: 11979833
• Formula Weight: 1363.6
• Percent Purity: >95%
• Chemical Name or Material: TMPyP4 tosylate